A-lipoic acid is a substance that resembles vitamins and can be described generally as a powerful antioxidant.
Although healthy young people can produce in their bodies enough lipoic acid in order to neutralize the negative oxidative effects of free radicals that circulate the human body and to help the activity of other endogenous antioxidants agents (glutathione, vitamin C and vitamin E), however, since the human body ages, the level of the lipoic acid in the organism falls, reducing further its antioxidant defense, fact that can lead to health problems. Many studies, indicate, that the lipoic acid regulates the proper record of genes who are responsible for registering the antioxidant and the inflammatory actions of human body (Park S, Curr Med Chem. 2014).
There is plenty of evidence in controlled studies with placebos but in literature, showing that lipoic acid is an effective and safe additional treatment, especially for the diabetic neuropathy where it can result in significantly improved clinical improvements (Papanas N, Expert OpinPharmacother. 2014 Dec).
Additionally, there are scientific studies, showing that when diabetic Type 2 patients received additional treatment with lipoic acid in doses of:
- 300 mg daily for 8 weeks there was a significant reduction in the fasting glucose (Ansar H Saudi Med J. 2011 Jun).
- 400mg daily for 4 weeks there was an improvement in levels of “good” cholesterol and reduction in levels of oxidant stress of their organism (Gianturco VArch Gerontol Geriatr. 2009;49 Suppl).
- 900mg daily for 12 weeks the levels of fructosamine were reduced (Evans JL Endocr Pract. 2002 Jan–Feb)
- 600,1200 and 1800mg daily for 4 weeks improved their sensitivity- correspondence in the insulin (Jacob S FreeRadic Biol Med. 1999 Aug).
- 600mg daily with or without vitamin E, for 4 months, improved the resistance index to the action of the insulin and blood lipid levels (de Oliveira AM Diabetes Res Clin Pract. 2011 May).
- 300, 600, 900 and 1200mg daily reduced both the fasting glucose and the glycosylated hemoglobin. The larger doses of lipoic acid were more efficient in this case (Porasuphatana S Asia Pac JClin Nutr. 2012).